$23 million for breast cancer research

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A state-run breast malignant neoplastic disease organisation is offering $23 million in grants to men of science studying the environmental causes of breast malignant neoplastic disease and why some groupings of women look to be at greater hazard based on their ethnicity or where they live.

The Golden State Breast Cancer Research Program announced the support programme Tuesday at the yearly American Association of Cancer Research convention in San Diego.

Experts with the state programme identified respective countries of research that have got been overlooked by national fundraising efforts, said Marion Kavanaugh-Lynch, manager of the program. For example, research workers have got got not yet determined why Marin County and the Bay Area have higher rates of breast malignant neoplastic disease than the remainder of the state and country. Scientists also don't yet understand why achromatic women have got higher breast malignant neoplastic disease rates than achromatic women.

Funding will travel toward 10 research topics, including women's exposure to chemicals throughout their lives and what function a woman's ethnicity plays in her diagnosing and long-term survival. Grant money also will travel toward two big surveys involving more than than 330,000 women.

Breast Cancer 3-Day back to Cleveland - WKYC-TV

Cleveland -- People will walk 60 statute miles in three years to struggle breast cancer.

The Cleveland community will see one thousands of people walking together August 22-24 when the Breast Cancer 3-Day tax returns to the Cleveland country as portion of its 2008 series. This is the 2nd twelvemonth the Breast Cancer 3-Day, a three-day, 60-mile walk elevation finances for and consciousness of breast cancer, have been in Cleveland. In 2007, more than than 1,100 Walkers participated in the Cleveland Breast Cancer 3-Day. Each Walker perpetrates to a fundraising a lower limit of $2,200, helping to raise billions of dollars for donees Susan G. Komen for the Cure® and the National Philanthropic Trust Breast Cancer Fund. Return monetary fund advanced and life-saving breast malignant neoplastic disease research, instruction and community outreach programs. The Breast Cancer 3-Day is a alone event because the Walkers word form a community among themselves from the minute they subscribe up through their last stairway into shutting ceremonies. Upon registration, participants are able to fall in teams, go to helpful meetings and ran into new friends during preparation walks. The sense of community is only heightened on-event when the Walkers pass all twenty-four hours together on the path and then go back to camp, their home-away-from-home, and chemical bond over hot meals, cheerful amusement and cosy pinkish two-person sleeping tents. Participants traveling an norm of 20 statute miles a twenty-four hours during each Breast Cancer 3-Day event, raising consciousness for breast malignant neoplastic disease throughout the streets and the mass media nationwide. Participants are provided meals, snacks, liquids, mobile showers, safety guidelines, 24-hour medical support ? all resources Walkers necessitate for a safe and memorable experience. Nationally, the events bring forth billions of dollars to fund critical breast malignant neoplastic disease research and community outreach programs.The Breast Cancer 3-Day is an chance to educate 10s of one thousands of people about breast health, including the importance of early detection. Return from the Breast Cancer 3-Day benefit the breast malignant neoplastic disease movement, grassroots activism and community outreach programmes of Susan G. Komen for the Remedy and the National Philanthropic Trust Breast Cancer Fund. Call 1-800-996-3DAY for up-to-date information and a 2008 event schedule.

Faulty gene link to breast cancer

Scientists say they have linked a faulty copy of a gene with the development of breast cancer.

Researchers in London and Italy studying biopsies found that Tip60 did not work as actively in breast cancer tissue as it did in normal tissue.

Low Tip60 activity was particularly associated with aggressive tumours.

The scientists said their findings, which are published in Nature, had implications for the treatment of women with the disease.

If low levels of Tip60 activity suggest a woman has a particularly aggressive form of the disease, she could be treated accordingly.

"More aggressive types of breast cancers tend to recur after treatment, spread to other parts of the body, and respond less well to chemotherapy," said Dr Tim Crook, the team leader at The Breakthrough Breast Cancer Research Centre.

"The identification of Tip60's role in breast cancer is a step forward towards predicting the aggressiveness of the disease and then individualising chemotherapy for women."

One faulty gene

Tip60 is a so-called tumour suppressor gene: it helps to hold the growth of cells in check.

Scientists found that reduced activity of the gene contributed to uncontrolled cell growth, which in turn allowed breast cancer to develop.

They also found that reduced levels of Tip60 were caused by only one faulty copy of the gene.

When we are born we inherit a copy of the gene from our mother and our father. Typically with tumour suppressor genes, both copies must be faulty for the function to be lost.

But the scientists said that the Tip60 gene stops working if only one copy is faulty.

Antonia Dean of Breast Cancer Care said scientists were still a long way from fully understanding the role genes play in the development of breast cancer, "and how this interacts with or is mediated by other factors".

"This is initial research. Further studies are needed to fully determine how these findings can be translated into practical benefits for people with breast cancer and the exact role Tip60 may have in the development of the disease."